Medicinal Chemistry

Target compound discovery (HI), lead compound discovery (LG) and lead compound optimization (LO):

• Architectural design for compound discovery;

• Preliminary intellectual property analysis of the new design framework;

• Synthesize compound libraries for lead compound discovery (LG) and lead compound optimization (LO);

Synthetic Chemistry

Design synthetic route and compound research and development:

• Organic chemistry: novel compounds with arbitrarily complex structures;

• Chiral chemistry: chiral asymmetric synthesis, optical resolution and chiral separation (HPLC, SFC);

• Bio-organic chemistry: including nucleosides, nucleotides, sugars, peptides, lipids, antibody drug coupling agents;

• Combinatorial chemistry: large compound libraries with diversified structures and compound libraries for certain targets;

Synthesize reference compounds, intermediates, candidate drugs, impurities and metabolites and other small molecule chemical substances for compound synthesis, chemical synthesis, peptide synthesis, protein synthesis, pharmaceutical intermediate synthesis, generic drug synthesis, chemical synthesis:

Process Development

Committed to the development of stable and low-cost processes suitable for large-scale production (chemical process research, drug synthesis process optimization, pharmaceutical process, preparation process, etc.):

• Selection of commercialization routes;

• Definition of GMP starting materials;

• Research on the structure, source and control of impurities;

• Unit operation research and confirmation of key process parameters in each step;

• Development and optimization of commercial processes through reaction design (DoE) and quality design (QbD);

Process Analysis Range

Analysis method development, validation and verification include:

• Weight content and purity;

• relative substance;

• Water content;

• Chiral analysis;

• solvent remains;

• Trace elements;

• Central control and release;

• Impurity separation and structure identification;

• Standardization of reference materials;

• Stability research;

• Development, verification and testing of analytical methods for potential genotoxic impurities;

• Formulation of specifications and other declaration documents;

Laboratory Equipment For Analysis:

• Chromatography: UPLC, HPLC, LC-MS, GC, IC, SFC

• Solid-state characterization analysis: differential scanning calorimeter (DSC), thermogravimetric analyzer (TGA), X-ray powder diffraction (XRPD), particle size analyzer (PSD), polarized light microscopy (Polarized light microscopy)

• Analysis and identification: nuclear magnetic resonance (NMR), Fourier transform infrared spectroscopy (FT-IR)

• General test: moisture meter (KF), ultraviolet and visible spectrum (UV-Vis), polarimeter (Polarimeter)